Effects on A-V conduction of tetrodotoxin selectively injected into the A-V node artery of the dog.

IIJIMA, T., MOTOMURA, S., TAIRA, N. and HASHIMOTO, K. Effects on A-V Conduction of Tetrodotoxin Selectively Injected into the A-V Node Artery of the Dog. Tohoku J. exp. Med., 1972, 107 (1), 99-100 „Ÿ Tetrodotoxin was injected selectively into the A-V node artery of the dog heart in situ, of which both vagi and both cardiac nerves were cut. Tetrodotoxin at doses of 1 to 3 μg abolished effects of electrical stimulation of either the left vagus or the left cardiac nerve on A-V conduction without any direct effect on A-V conduction. A very large dose